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Selective functionalization of benzylic C(sp³)-H bonds to synthesize complex molecules

Tijdschriftbijdrage - Tijdschriftartikel

Functionalization of the benzylic C(sp(3))-H bond has become a compelling and robust tool to speed up pre-clinical research for "lead discovery. "Besides bring frequently utilizated to construct complex molecules in total synthesis, this emerging strategy of benzylic C(sp(3))-H bond functionalization has facilitated site-selective modifications of complex molecules. Here, we have summarized recent benzylic C(sp(3))-H bond functionalization applications for synthesizing complex molecules. We have carefully addressed recent applications in this topic, ranging from the site-selective modifications using benzylic C-H bond functionalization to the total synthesis of natural products. This review will recount the formation and application of new C-C, C-O, C-N, and C-X (X = halogens, sulfur, etc.) bonds to provide a clear blueprint for and deep insight into the functionalization of benzylic C-H bonds.
Tijdschrift: Chem
ISSN: 2451-9294
Volume: 8
Pagina's: 3175 - 3201
Jaar van publicatie:2022
Trefwoorden:A1 Journal article
Toegankelijkheid:Closed