Troyan horses in the central nervous system: do extracellular vesicles govern neuroinflammation and alpha-synuclein propagation? KU Leuven
For 20 years, researchers and clinicians have been disentangling the critical role of -synuclein (aSYN) in protein aggregation and neuronal death in Parkinson’s disease (PD). More recently, they also discovered that aSYN mediates propagation of PD pathology across different brain regions, thereby leading to progressive worsening of the disease. The current project proposal is centered on the so-called ‘prion hypothesis’ of aSYN propagation ...