BRIP1 controlling replicative stress in the neuroblastoma tumor genome: functional exploration and zebrafish modelling Ghent University
Neuroblastoma is a tumor arising in the nervous system and almost exclusively exist in children younger than five. Unfortunately, half of these tumors are very aggressive and still extremely difficult to cure. In recent decades it has been shown that neuroblastoma tumors almost have no mutations, but instead a lot of copy number alterations occur. One of these copy numbers is gain of 17q which is correlated with poor patient outcome. In this ...