Transgenic Expression of the Vitamin D Receptor Restricted to the Ileum, Cecum and Colon of Vitamin D Receptor Knockout Mice Rescues Vitamin D Receptor Dependent Rickets KU Leuven
Although the intestine plays the major role in 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] action on calcium homeostasis, the mechanisms involved remain incompletely understood. The established model of 1,25(OH)2D3-regulated intestinal calcium absorption postulates a critical role for the duodenum. However, the distal intestine is where 70% to 80% of ingested calcium is absorbed. To test directly the role of 1,25(OH)2D3 and the vitamin D receptor ...