Projects
Antiviral mechanism and visualization of the interferon induced protein Mx1 Ghent University
Our aim is to identify how Mx1 protein can suppress influenza A virus replication by using advanced microscopy techniques and performing functional assays.
The development of novel quenched fluorescent activity-based probes and their application in the visualization of serine protease activity in living cells by microscopy and flow cytometry KU Leuven
Proteases are enzymes that cut proteins. Although some play a role in food digestion, most are involved in the regulation of specific biological processeses in the body. Aberrant protease activity contributes to the development of diseases, and proteases can therefore be used as drug targets and diagnostic markers. For example, some tumor types display an increased protease activity. If we were able to localize a particular protease and show ...
The synthesis and application of novel activity-based probes for the visualization of cysteine proteases. KU Leuven
Proteases are enzymes that cut proteins by catalyzing the hydrolysis of the peptide bond. They can be found in almost every organism, where they play a part in many biological pathways and are involved in various human diseases. For example, cathepsins, a class of cysteine proteases, are upregulated in various cancers, making them an interesting biomarker and suitable targets for tumor labeling.
An excellent method for the detection of ...
Developing a multiphysics computational model to support thermosonics for efficient defect visualization KU Leuven
In recent years, thermosonics has gained a tremendous amount of interest as one of the popular Non-Destructive Testing (NDT) techniques in order to localise a possible internal defect. In general, NDT techniques gather information about the inside of a material, without destroying the material, or potentially enlarging the present damage. In the specific case of thermosonics, the studied sample is first activated by an ultrasonic ...
Methylation in situ hybridization: visualization of methylation patterns using UPSAS Ghent University
MISH kan worden toegepast voor de diagnose van prostaatkanker in kleine biopten of in cytologiemonsters van neoplastische cellen in de urine van patiënten. Momenteel is onderzoek en diagnose van methylatiemarkers een zeer duur proces, waarvan de prijs kan worden verlaagd door MISH (er is bijvoorbeeld geen DNA-extractie vereist); MIVH kan ook worden geautomatiseerd voor analyses met hoge doorvoer. MIVH kan daarom een beter alternatief bieden ...
In Search of Meaning: Thinking Information Visualization within Art History Research KU Leuven
This dissertation presents our work at the intersection of Art History (AH) and Information Visualization (InfoVis). In this text, we describe our efforts towards understanding the relationship between AH and InfoVis scholarship, along with conceptual and practical contributions to the growing interest in Digital Art History.
More concretely, this dissertation aims to answer the following research questions:
RQ1: How can we design ...
Advanced multimodal data analysis and visualization of composites based on grating interferometer micro-CT data (ADAM). University of Antwerp
Testing viral evolutionary hypotheses using Bayesian phylogenetic inference and visualization. KU Leuven
In this project, I propose to work on state-of-the-art Bayesian phylogenetic inference and visualisation techniques to investigate the phylodynamics of pathogens.Specifically, I will advance a model to capture how evolutionary processes change through time by implementing the capability to incorporate and test covariates. I will design a stochastic modeling approach with associated inference machinery to detect variation in natural selection ...
Scalable Software Solutions for Visualization and Analysis of Complex Data KU Leuven
My research concerns hypothesis-free exploration and visualization of high-dimensional data sets. One of the goals is to implement a quality-metric guided visualization pipeline that guides the user through the different stages of exploring hidden structures embedded in the plethora of dimensions of the data. This pipeline leverages recent advances in the field of distributed resource-sharing and computation platforms. We aim to test and ...