Projects
Replacement of confocal fluorescence microscope for visualisation of biological processes in humans and animals Ghent University
The confocal fluorescence microscope Leica TCS SP2 Laser Scanning Spectral Confocal System, localized in the Laboratory of Virology, Faculty of Veterinary Medicine is a device that is daily used by different users of the Faculties of Veterinary Medicine and Medicine and Health Sciences for the research on different biological processes (pathogenesis, immunopathology, embryology, …). It is ...
Risk assessment kit: from data acquisition to risk visualization Ghent University
The overal objective is to create a toolbox and methodology to produce useful and accurate risk maps
In the doctoral research of Hanne Glas, a flexible methodology for flood risk assessment in developing and data-poor regions was developed. Furthermore, the first steps were taken towards the creation of a risk mapping toolbox. In this project, the existing methodology will be extended to a comprehensive multi-hazard ...
VisioFlow: Developing models for two-phase flow through geological porous media based on visualization experiments Hasselt University
The synthesis and application of novel activity-based probes for the visualization of cysteine proteases. KU Leuven
Proteases are enzymes that cut proteins by catalyzing the hydrolysis of the peptide bond. They can be found in almost every organism, where they play a part in many biological pathways and are involved in various human diseases. For example, cathepsins, a class of cysteine proteases, are upregulated in various cancers, making them an interesting biomarker and suitable targets for tumor labeling.
An excellent method for the detection of ...
Methylation in situ hybridization: visualization of methylation patterns using UPSAS Ghent University
MISH kan worden toegepast voor de diagnose van prostaatkanker in kleine biopten of in cytologiemonsters van neoplastische cellen in de urine van patiënten. Momenteel is onderzoek en diagnose van methylatiemarkers een zeer duur proces, waarvan de prijs kan worden verlaagd door MISH (er is bijvoorbeeld geen DNA-extractie vereist); MIVH kan ook worden geautomatiseerd voor analyses met hoge doorvoer. MIVH kan daarom een beter alternatief bieden ...
Testing viral evolutionary hypotheses using Bayesian phylogenetic inference and visualization. KU Leuven
In this project, I propose to work on state-of-the-art Bayesian phylogenetic inference and visualisation techniques to investigate the phylodynamics of pathogens.Specifically, I will advance a model to capture how evolutionary processes change through time by implementing the capability to incorporate and test covariates. I will design a stochastic modeling approach with associated inference machinery to detect variation in natural selection ...
Visualization of biomolecular interactions and sensing in living systems with super-resolution fluorescence microscopy. KU Leuven
Fluorescence microscopy is a powerful method to study living systems with high spatial and temporal resolution. However, the resolution of a conventional microscope is limited by diffraction, which precludes the direct visualization of many biological processes occurring at their small scale. During the last decade, several super-resolution fluorescence microscopy methods have been developed that break this diffraction limit and offer a new ...