Towards the development of potent and selective inhibitors of hepatitis E virus. KU Leuven
Hepatitis A and E virus are the most prominent causes of acute viral hepatitis worldwide (chapter 1). Despite the availability of an effective vaccine for hepatitis A virus (HAV), it is widespread in developing countries and outbreaks still occur regularly in industrialized regions. Although most infections are asymptomatic, or have a mild clinical course, severe cases of hepatitis A may occur, especially in the elderly. The availability of ...