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Chlamydial biology and its associated virulence blockers Ghent University
Ethylene production during Alternaria infections on potato plants and its antagonistic role in virulence of different Alternaria species Ghent University
Alternaria species are notorious pathogens of solanaceous crops and are known to produce a plethora of toxins. Nevertheless, the involvement of toxins or other virulence factors in Alternaria infections on potato plants has never been investigated. In view of this, we analysed whether different Alternaria species produced host- and non-host-specific toxins in vitro and in vivo. Secondly, we assessed if ethylene (ETH) is involved in potato plant ...
Whole genome sequencing to study antimicrobial resistance and RTX virulence genes in equine Actinobacillus isolates Ghent University
Virulence and antimicrobial resistance profiling of Salmonella serovars recovered from Retail Poultry Offal in KwaZulu-Natal Province, South Africa Ghent University
As poultry organ meat is widely consumed, especially in low- and middle-income countries, there is reason to investigate it as a source of Salmonella infections in humans. Consequently, the aim of this study was to determine the prevalence, serotypes, virulence factors and antimicrobial resistance of Salmonella isolated from chicken offal from retail outlets in KwaZulu-Natal, South Africa. Samples (n = 446) were cultured for the detection of ...
Genomic analysis of Yersinia pestis strains from Brazil: search for virulence factors and association with epidemiological data Institute of Tropical Medicine
Yersinia pestis, the etiological agent of the plague, is considered a genetically homogeneous species. Brazil is currently in a period of epidemiological silence but plague antibodies are still detected in sentinel animals, suggesting disease activity in the sylvatic cycle. The present study deployed an in silico approach to analyze virulence factors among 407 Brazilian genomes of Y. pestis belonging to the Fiocruz Collection (1966–1997). The ...
Virulence factor genes in invasive Escherichia coli are associated with clinical outcomes and disease severity in patients with sepsis : a prospective observational cohort study Ghent University Hasselt University
Background: Escherichia coli harbours virulence factors that facilitate the development of bloodstream infections. Studies determining virulence factors in clinical isolates often have limited access to clinical data and lack associations with patient outcome. The goal of this study was to correlate sepsis outcome and virulence factors of clinical E. coli isolates in a large cohort. Methods: Patients presenting at the emergency department whose ...
Virulence factors and antimicrobial resistance in Salmonella species isolated from retail beef in selected KwaZulu-Natal municipality areas, South Africa Ghent University
Salmonellosis and antimicrobial resistance caused by non-typhoidal Salmonella are public health concerns. This study aimed at determining prevalence, serovars, virulence factors and antimicrobial resistance of Salmonella from beef products. Four-hundred beef samples from 25 retail outlets in KwaZulu-Natal, South Africa were analyzed for Salmonella using standard methods, confirmation with matrix-assisted laser desorption ionization-time of ...
Lentils and yeast fibers : a new strategy to mitigate enterotoxigenic Escherichia coli (ETEC) strain H10407 virulence? Ghent University
Dietary fibers exhibit well-known beneficial effects on human health, but their anti-infectious properties against enteric pathogens have been poorly investigated. Enterotoxigenic Escherichia coli (ETEC) is a major food-borne pathogen that causes acute traveler's diarrhea. Its virulence traits mainly rely on adhesion to an epithelial surface, mucus degradation, and the secretion of two enterotoxins associated with intestinal inflammation. With ...
Antimicrobial resistance and virulence characteristics in 3 collections of staphylococci from bovine milk samples Research Institute for Agriculture, Fisheries and Food Ghent University
Mastitis is a prevalent disease in dairy cattle, and staphylococci are among the most common causative pathogens. Staphylococci can express resistance to a range of antimicrobials, of which methicillin resistance is of particular public health concern. Additionally, Staphylococcus aureus carries a variety of virulence factors, although less is understood about the virulence of non-aureus staphylococci (NAS). The aim of our study was to identify ...