Publications
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ETEC virulence factors modulate the intestinal immune system Ghent University
4th FEMS. Inciddence and virulence factors of verocytotoxin-producing Escherichia coli in the Brussels capital region (Belgium). Vrije Universiteit Brussel
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Epidemiological and genetic markers, virulence factors and intracellular growth of Mycobacterium avium in AIDS Institute of Tropical Medicine
Secretome analysis identifies potential virulence factors of Diplodia corticola, a fungal pathogen involved in cork oak (Quercus suber) decline Ghent University
Virulence factor genes in invasive Escherichia coli are associated with clinical outcomes and disease severity in patients with sepsis : a prospective observational cohort study Ghent University Hasselt University
Background: Escherichia coli harbours virulence factors that facilitate the development of bloodstream infections. Studies determining virulence factors in clinical isolates often have limited access to clinical data and lack associations with patient outcome. The goal of this study was to correlate sepsis outcome and virulence factors of clinical E. coli isolates in a large cohort. Methods: Patients presenting at the emergency department whose ...
Evidence for viral virulence as a predominant factor limiting human immunodeficiency virus vaccine efficacy Institute of Tropical Medicine
Comparative chemical screening and genetic analysis reveal tentoxin as a new virulence factor in Cochliobolus miyabeanus, the causal agent of brown spot disease on rice Research Institute for Agriculture, Fisheries and Food Ghent University
Brown spot disease, caused by Cochliobolus miyabeanus, is currently considered to be one of the most important yield reducers of rice (Oryza sativa L.). Despite its agricultural importance, little is known about the virulence mechanisms deployed by the fungus. Therefore, we set out to identify novel virulence factors with a role in disease development. This article reports, for the first time, the production of tentoxin by C. miyabeanus as a ...
Differential dynamics and impacts of prophages and plasmids on the pangenome and virulence factor repertoires of Shiga toxin-producing Escherichia coli O145:H28 Vrije Universiteit Brussel
Phages and plasmids play important roles in bacterial evolution and diversification. Although many draft genomes have been generated, phage and plasmid genomes are usually fragmented, limiting our understanding of their dynamics. Here, we performed a systematic analysis of 239 draft genomes and 7 complete genomes of Shiga toxin (Stx)-producing Escherichia coli O145:H28, the major virulence factors of which are encoded by prophages (PPs) or ...
Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids University of Antwerp Flanders Institute for Biotechnology Vrije Universiteit Brussel
Human African trypanosomiasis or sleeping sickness, caused by the protozoan parasite Trypanosoma brucei , is characterized by the manipulation of the host’s immune response to ensure parasite invasion and persistence. Uncovering key molecules that support parasite establishment is a prerequisite to interfere with this process. We identified Q586B2 as a T. brucei protein that induces IL-10 in myeloid cells, which promotes parasite infection ...