Projects
Bacterial and host factors involved in gastric colonization and induction of lesions by Helicobacter suis and Helicobacter heilmannii Ghent University
The aims of this project are to investigate how non-Helicobacter pylori helicobacters colonize and damage the stomach of animals and humans. To achieve this, bacterial factors involved in colonization of the gastric mucosa, induction of host cell death and modulation of the host immune response will be characterized.The aims of this project are to investigate how non-Helicobacter pylori helicobacters colonize and damage the stomach of ...
Bacterial and host factors involved in gastric colonization and induction of lesions by Helicobacter suis and Helicobacter heilmannii Ghent University
The aims of this project are to investigate how non-Helicobacter pylori helicobacters colonize and damage the stomach of animals and humans. To achieve this, bacterial factors involved in colonization of the gastric mucosa, induction of host cell death and modulation of the host immune response will be characterized.The aims of this project are to investigate how non-Helicobacter pylori helicobacters colonize and damage the stomach of ...
Identifying factors involved in miltefosine or amphotericin B treatment failure in visceral leishmaniasis. University of Antwerp
Viral and cellular factors that determine virus replication and clinical picture during infections with equine arteritisvirus in horse Ghent University
Infections with equine arteritis virus have different clinical outcomes. They are either subclinical, or clinical with only reproductive failure, or clinical with severe clinical signs (oedema, fever, respiraotry problems, colic). The etiology of this different clinical outcome is not known and will be examined in the present project. Special attention will be paid to differences in cell tropism and its basis.
Diagnosis of Helicobacter Heilmannii sensu stricto infections in dogs, cats and humans Ghent University
Helicobacter (H.) pylori is the most prevalent Helicobacter species colonizing the gastric
mucosa of humans and has been associated with gastritis, peptic ulcer disease and gastric
cancer. This slightly-curved, Gram-negative and microaerophilic gastric bacterium is highly
adapted to the human host and has succeeded to colonize more than 50% of the human
population worldwide. Besides H. pylori, other spiral-shaped ...
Unraveling the sugar metabolism of Candida albicans to find new antifungal drugs KU Leuven
Candida albicans is an opportunistic fungal pathogen which infection rate became more frequent over the last years. Another problem is their rising resistance against the available antifungal drugs on the market, like fluconazole. Therefore, C. albicans is a relevant health problem and there is an urgent need for new antifungal drugs with a complete novel mode of action to counteract the spread of this fungus. To colonize the human body this ...
Histomonas meleagridis in turkeys: a quest for protection against histomonosis KU Leuven
Histomonas meleagridis is a single eukaryotic microorganism causing infectious enterohepatitis in galliform birds with high mortality, notably in turkeys. This fastidious disease is also called ‘histomonosis’. Upon initial infection, the protozoan flagellate H. meleagridis resides in the bird caeca and multiplies in the caecal lumen from where the protozoa will infiltrate the host intestinal tissue. Proceeding the ...
Exploiting polymersomes to create 'smart' wound dressings with diagnostic and antimicrobial capabilities Ghent University
One of the major issues present in open wound management is bacterial infection. To tackle this issue, within the proposed project, a novel and ‘smart’ polymer-based wound dressing will be developed which maintains the moisture balance and holds additionally both diagnostic and antimicrobial properties. Nanovesicles will be applied starting from polymersomes whereby part will be loaded with a self-quenched dye and part with an antimicrobial ...
Exploiting polymersomes to create 'smart' wound dressings with diagnostic and antimicrobial capabilities KU Leuven
One of the major issues present in open wound management is bacterial infection. To tackle this issue, within the proposed project, a novel and ‘smart’ polymer-based wound dressing will be developed which maintains the moisture balance and holds additionally both diagnostic and antimicrobial properties. Nanovesicles will be applied starting from polymersomes whereby part will be loaded with a self-quenched dye and part with an antimicrobial ...