Projects
Virtual Plant Tissue Generation Based on Cell Growth Modeling. KU Leuven
Plants and plant organs respond to changes in the environment through metabolic processes such as transpiration, respiration and photosynthesis that involve transport of metabolic compounds in and between tissues and cells. Plants have a wide variety of tissues and cell types, and it is likely that their microstructural geometry affects these processes. As experimental characterisation of transport processes at this scale is not ...
Active learning and interpretation of computational model on tissue specific permeability for stock and virtual drug discovery library KU Leuven
Development of a novel diagnotic assay for the biochemical diagnosis of mitochondrial disorders in vital tissue KU Leuven
Primary mitochondrial disorders are characterized by aberrancies in normal mitochondrial functioning due to mutations in either nuclear or mitochondrial DNA-encoded genes. The estimated prevalence is at least 1 in 5.000 births, suggesting that there are at least 1.200 individuals in Flanders with an inherited mitochondrial disorder. However, less than 250 patients in Flanders have a diagnosis. We follow approximately 100 patients with a ...
A new era of virtual histology: novel contrast agents for 3D multi-tissue imaging using contrast-enhanced computed tomography KU Leuven
Biological tissues have a spatial heterogeneity. Thus, 2D measurements like histomorphometry only partially reveal their full 3D morphology. We propose contrast-enhanced computed tomography (CE-CT) for 3D structural quantification of biological tissues and 3D immunological imaging. Previously, we explored commercially available and in-house synthesized contrast agents (polyoxometalates - POMs). In this project, as pioneers in the field, we ...
Virtual Staining KU Leuven
VIrtual Twins as tools for personalised clinicAL care (VITAL) Ghent University
VITAL will deliver a comprehensive clinically validated multi-scale, multi-organ modelling platform that is driven by and can represent individual patient data acquired, both in the clinic and from wearable technology. The platform will create a virtual human twin for individualised and sex-specific optimisation of medical (pharmacological) or surgical (interventional) therapy for complex, multifactorial cardiovascular disorders that have ...
Large area tactile and kinaesthetic display system for virtual reality palpation. KU Leuven
In a normal robotic surgical procedure only vision and position feedback is available. Without an equivalent to the sense of touch the surgeon cannot rely anymore on palpation to differentiate between healthy and sick tissue, or to find his/her way into complex often fragile body areas. The proposed research is dedicated to restore the sense of touch, in all its facets, to the surgeon in a robotic surgical procedure where the robot touches ...
In-silico Development- and Clinical-Trial-Platform for Testing in-situ Tissue Engineered Heart Valves KU Leuven
SimInSitu is aiming to develop a sophisticated in-silico method to predict the short- and long-term behavior of in-situ tissue engineered heart valves by combing advanced tissue remodeling algorithms with a personalized virtual heart modelling approach. The method will be specifically developed to predict the complex transformation process of biodegradable heart valves from the initially synthetic scaffold into a fully remodeled & ...
Unraveling the molecular and cellular basis of vascular tissue formation Ghent University
Plant cells are organised in files along the body axis and growth is maintained through divisions within these files of cells. In order to create a new three-dimensional organ however, plants trigger cells in a specific zone to undergo a different type of division, forming additional cell files. Vascular cells have the specific ability to undergo many of these formative divisions, generating the tissues that make up wood in trees and that are ...