Projects
Host cell phosphatases in the life cycle of DNA viruses KU Leuven
HIV nuclear import and chromatin reading as novel drug targets KU Leuven
The replication cycle of HIV is a complicated interplay between viral and cellular proteins. Until now antiretroviral therapy mainly targets the viral proteins although the interaction between the viral and cellular proteins could be interesting new drug targets. This strategy is mainly of interest because cellular proteins are much less prone to mutations which gives the virus less opportunity to develop drug resistance. My laboratory has ...
Novel HIV inhibitors targeting the interaction between integrase and LEDGF/p75 KU Leuven
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Platform development for combining fluorescent and electrical detection of single molecules towards DNA mapping. KU Leuven
Throughout our history, we, humans, have sought to better control and understand our environment. To this end, we have extended our natural senses with a host of sensors—tools that enable us to detect both the very large, such as the merging of two black holes at a distance of 1.3 billion light years from earth, and the very small, such as the identification of individual viral particles from a complex mixture. This dissertation is devoted to ...
Single virus imaging of early steps of HIV replication KU Leuven
The granular origins of macroeconomic fluctuations. KU Leuven
This research program wants to provide a new and different approach to analyze macroeconomic performance, by recognizing that heterogeneous behavior of the underlying micro economic parts provide important new insights about the channels of macroeconomic fluctuations. This approach is sometimes also referred to as the ‘granular origins’ of aggregate fluctuations. The program is structured along various micro data sets that have been developed ...