Understanding Drug-Induced Cholestasis: Mechanistic exploration of hepatic bile acid disposition KU Leuven
Drug-induced liver injury (DILI) is the most frequent reason for drug withdrawal from the market (Xu et al., 2004; Atienzar et al., 2016). Hence, DILI poses a major risk for patient health and pharmaceutical industry. Nowadays, pharmaceutical industry is still confronted with the poor prediction of DILI in non-clinical safety environment during drug development. The current non-clinical in vivo animal tests are not ...