Metabolically engineered organisms for the production of added value bio-products Ghent University
By metabolically engineering E. coli a ‘plug’ strain is being developed that is an efficient producer of specialty carbohydrates. The rationale of the developed strategy is that sucrose an abundantly present and inexpensive substrate is split into glucose-1-phosphate and fructose. Glucose-1-phosphate is used to fuel the metabolically engineered production pathway for the specialty carbohydrate, while the microbial reactions for the synthesis of biomass and the numerous bio-catalytic enzymes that will perform the conversion of glucose-1-phosphate to the specialty carbohydrate, are fuelled by ...