Target validation and drug discovery towards a therapy for the Rett Syndrome. KU Leuven
Rett syndrome (RTT) (OMIM 312750) is a progressive neurodevelopmental disorder that predominantly affects girls and is caused by loss-of function mutations in the methyl-CpG-binding protein 2 (MeCP2). To date only symptomatic treatment is available. In this project we will validate on the one hand the direct interaction between the transcriptional co-activator lens epithelium-derived growth factor p75 (LEDGF/p75) and MeCP2 as a putative ...