Kinetic models for different retention solutes like the protein-bound solutes are calibrated and validated based on in vitro and in vivo data. These models are further used to develop a new parameter to indicate hemodialysis adequacy as well as to optimise and personalise the hemodialysis treatment.
Retention of uremic solutes as well as renal replacement therapy contribute to micro-inflammation related to the cardial burden in chronic kidney disease. Especially the effect of uremic peptides on leukocytes and specific leukocyte subpopulations will be evaluated in an in vitro set-up. The pathophysiological mechanisms involved, will be elucidated, aiming at a classification of the retention solutes according to their toxicity.
Patients with renal failure retain a large variety of uremic retention solutes and are currently treated with a blood purifying technique like hemodialysis. To optimise this treatment, kinetic models, calibrated with clinical data, were developed, simulating solute transport in between different virtual body compartments. These models were further used to simulate different dialysis strategies.
The colonic microbial metabolism is an important source of uremic retention solutes accumulating in patients with chronic kidney disease and higher serum levels of microbial metabolites have been related to overall mortality, cardiovascular disease and progression of pre-existing renal disease. The interaction between the colonic microbial metabolism and renal function has been coined the ‘gut-kidney axis’.
Although it has ...