Single-molecule multi-omics to study tumour heterogeneity and evolution KU Leuven
Cancer is a chiefly genetic disease, originating from the acquisition of somatic mutations in cells throughout our life. While most of these mutations are innocuous passengers, a handful unlock the typical hallmarks of cancer. The latter endow a cell with a fitness advantage relative to neighbouring cells, leading to a clonal outgrowth. Clonal expansions can be shaped by the evolutionary processes of selection and drift, which act on the ...