Publications
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Vrije Universiteit Brussel
Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population KU Leuven
Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression Vrije Universiteit Brussel
The current review article describes the functional relationship between tumor-associated macrophages (TAM) as key cellular contributors to cancer malignancy on the one hand and macrophage-colony-stimulating factor (M-CSF or CSF-1) as an important molecular contributor on the other. We recapitulate the available data on expression of M-CSF and the M-CSF receptor (M-CSFR) in human tumor tissue as constituents of a stromal macrophage signature ...
Tumor-associated macrophages in breast cancer : distinct subsets, distinct functions. Vrije Universiteit Brussel
Ontogeny of tumor-associated macrophages Ghent University
Hypoxia and tumor-associated macrophages : a deadly alliance in support of tumor progression Vrije Universiteit Brussel
Increase in tumor-associated macrophages after antiangiogenic therapy is associated with poor survival among patients with recurrent glioblastoma KU Leuven
The impact of hypoxia on tumor-associated macrophages KU Leuven
The Ontogeny and Microenvironmental Regulation of Tumor-Associated Macrophages Vrije Universiteit Brussel
SIGNIFICANCE: Tumor progression is supported by non-cancerous stromal cells, of which tumor-associated macrophages (TAMs) are prominent constituents. These cells could be considered promising therapeutic targets, but this requires a better understanding of their heterogeneity under the influence of tumor microenvironmental cues and/or ontogenic differences. Recent Advances: The availability of oxygen is an important regulator of the TAM ...