Projects
Establishment of an in vivo platform of patient-derived xenografts of several tumor types to study tailored cancer treatment. KU Leuven
This grant application is part of a large and ambitious project designed to set up a comprehensive in vivo platform for the establishment, characterization and preclinical exploration of PDTX of many different tumor types.
Investigation of DFNA5 as potential biomarker and tumour suppressor gene in 4 solid tumour types. University of Antwerp
Investigation of DFNA5 as potential biomarker and tumour suppressor gene in 4 solid tumour types. University of Antwerp
Taking ovarian cancer diagnosis to the next level: differential diagnosis of malignancy type, and added value of advanced data sources such as MRI, proteomics, circulating tumour DNA and circulating tumour cells KU Leuven
Excellent tools to predict whether a detected ovarian tumour is benign or malignant prior to surgery are pivotal for several reasons: (1) currently a minority of ovarian cancers is treated by experienced gynaecological oncologists, (2) the value of screening for ovarian cancer has not been established, and (3) ovarian cancer is largely asymptomatic in its early stages such that accurate diagnosis is paramount to optimize survival. The ...
The role of Tumor Micro-Environment in the pathogenesis and prognosis of EBV lymphomas: a study in human tumor biopsies and an novel Patient Derived Tumor Xenograft mouse model KU Leuven
For this PhD thesis we studied a set of rare B-cell lymphoproliferative disorders (LPDs): immunomodulation related lymphoproliferative disorders (IARLPD) and primary central nervous system lymphoma (PCNSL) using both classical and novel pathology techniques. We are currently expanding upon this research with an ongoing project studying EBV+ diffuse large B-cell lymphoma (EBV+ DLBCL). All with the aim of aiding the correct implementation of ...
Oxygen sensing machinery regulates tumor invasion by affecting tumor cells and tumor microenvironment KU Leuven
Circulating tumor DNA as an epigenetic marker of tumor behaviour KU Leuven
Specific tumor characteristics, such as molecular expression subtypes and hypoxia status, represent major predietors of patient prognosis and therapy response. For instance, patients with HER2-enriched breast tumor subtypes have a 2- fold increased risk of mortality, but uniquely benefit from Herceptin treatment. Likewise, hypoxic tumors are more prone to metastasis and show poor treatment responses. The routine detection of tumor subtypes or ...
Elucidating the role of CD11b+ conventional dendritic cells (cDC2) in the tumor microenvironment and their potential use as tumor vaccine. Vrije Universiteit Brussel
anti-tumor T cells are first activated in vivo is still incompletely ...