Projects
Determination of health-related biomarkers in livestock KU Leuven
Multi-centre Quantum Chemistry. KU Leuven
Amino Acid Needs of the Mealworm and Black Soldier Fly Larvae VIVES
Deciphering the molecular pathways needed to restore monocyte dysfunction during Acute-on-chronic liver failure KU Leuven
HIV nuclear import and chromatin reading as novel drug targets KU Leuven
The replication cycle of HIV is a complicated interplay between viral and cellular proteins. Until now antiretroviral therapy mainly targets the viral proteins although the interaction between the viral and cellular proteins could be interesting new drug targets. This strategy is mainly of interest because cellular proteins are much less prone to mutations which gives the virus less opportunity to develop drug resistance. My laboratory has ...
Diversity oriented synthesis based on the brevianamide scaffold for the development of physiologically active compounds Ghent University
The diketopiperazine scaffold is a preferred (sub)structure in a wide variety of physiologically active natural compounds, including brevianamide F (antibacterial), present in Streptomyces and Aspergillus species. The project aims at the synthesis of heterodiketopiperazine analogues with a less complicated structure than the active natural compounds or the synthesis of diketopiperazines with medicinal relevant substituents starting from amino ...
Study on the role of beta cell serotonin during pregnancy in the mouse. KU Leuven
Pregnancy is period in which the maternal body has to undergo several adaptations to meet the
demands of the fetus, for example in pancreatic beta cells. Pregnancy hormones stimulate prolactin
receptors (PRLRs) on beta cells to increase their capacity to produce insulin. In the last years, several
studies have been conducted on these changes in beta cells. Pancreatic islets of non-pregnant and
pregnant mice (at ...