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Translational research on chronic rejection after lung transplantation: Restrictive Allograft Syndrome after lung transplantation: exploring pathophysiological mechanisms and targeted therapy KU Leuven

Robin Vos
Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE)
Chronic lung allograft dysfunction (CLAD), the clinical correlate of chronic rejection, is the principal cause of late morbidity, mortality and excessive health-care costs following lung transplantation. The exact patho-physiological mechanisms in CLAD are incompletely understood. We will investigate risk factors for and mechanisms leading to CLAD, particulary for the phenotype called 'Restrictive Allograft Syndrome' (RAS), as well as novel ...

Translational research on chronic rejection after lung transplantation: towards better treatment in patients. KU Leuven

Bart Vanaudenaerde
Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE)

My BOF−ZAP project is part of the BREATHE research group and includes research into rejection after lung transplantation focusing on structural changes of the lung and the allo-immune response. This research ranges from basic experimental research in cell cultures and laboratory animals to translation to the human lung and the patient. The final objective remains to increase the quality and survival of the lung transplant patient. We aim to ...

DonoR-specific antilbodiES in cryo-bioPsIes and bRonchoAlveolar lavage fluid during rejecTIOn after luNg transplantation [Acronym: RESPIRATION] KU Leuven

Robin Vos
Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE)
Lung transplantation (LTx) is a life-saving treatment for patients with end-stage lung disease. Survival after LTx is limited due to development of chronic rejection of the transplant lungs, also termed chronic lung allograft dysfunction (CLAD), affecting 50% of patients within 5 years. Differences in human leukocyte antigens (HLA) between the donor and recipient (‘alloantigens’) are recognized by the recipient’s immune system, which ...

Technical optimisation and clinical validation of a novel urinary biomarker for antibody-mediated rejection after kidney transplantation KU Leuven

Maarten Naesens
Nephrology and Renal Transplantation Research Group
Donor-specific antibodies (HLA-DSA) can cause a severe form of transplant kidney rejection (antibody-mediated rejection; ABMR), which is currently difficult to treat with standard immunosuppressive therapy. Early stages of ABMR often occur subclinically but are detrimental to the functional survival of transplant kidneys. HLA-DSA testing is routinely performed, but this test is a risk factor for ABMR, not a diagnostic marker. Currently, no ...

Home-based PHysical rehabilitatiOn after livEr traNsplantation and Impact of eXercise intensity: a Randomized Controlled Trial [PHOENIX-RCT] KU Leuven

Diethard Monbaliu
Abdominal Transplantation, Department of Rehabilitation Sciences
Cardiovascular and metabolic morbidity and mortality following liver transplantation are a major problem. The etiology is primarily rooted in lifelong immunosuppressive therapy, a sedentary lifestyle, and poor physical fitness. We hypothesize that personalized home-based exercise training for 6 months, succeeded by a preference-tailored physical activity intervention in de novo liver transplant recipients is safe, cost-efficient, and effective ...

Wise men beyond borders. The transplantation of the French conseil de prud'hommes throughout Europe. Ghent University

Department of Interdisciplinary Study of Law, Private Law and Business Law

This research aims to map the transplantation of the French conseil de prudU+2019hommes across Europe and to compare its evolution in five countries in detail. This should enable us to gain insight into the development of specialised labour courts, but will also contribute to a much-needed clearer understanding of the conditions for a successful transplantation of legal rules or institutions.

Transcriptome-based management of transplant-related pulmonary fibrosis in chronic pulmonary rejection after lung or allogeneic stem cell transplantation KU Leuven

Robin Vos
Academic Centre for Nursing and Midwifery, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE)

Background Chronic lung allograft dysfunction (CLAD) and chronic pulmonary graft versus host disease (cGvHD) are life-threatening conditions commonly encountered after lung transplantation and allogeneic hematopoietic stem cell transplantation. Pathophysiological and molecular pathways associated with transplant-related pulmonary fibrosis leading to structural changes and lung failure in CLAD pulmonary cGvHD remain unknown. Aims The primary ...

Implementation of Machine learning and Personalized Algorithms for patient monitoring after Kidney Transplantation KU Leuven

Maarten Naesens
Nephrology and Renal Transplantation Research Group, Dynamical Systems, Signal Processing and Data Analytics (STADIUS)
In this multicenter HORIZON EUROPE consortium, we build on home-based applications, non-invasive biomarkers, and innovative image analysis, recently developed by the contributing partners. The project integrates clinical data and advanced molecular profiling of patients newly transplanted at major European kidney transplant centers. It aims to validate the previously developed artificial intelligence (AI) solutions for improved home-based ...

Integrated PK/PM Model-based Medication Dosing Assist App(lication) in KlinischWerkStation (KWS). Validation Studies of Tacrolimus in (Solid) Organ Transplantation KU Leuven

Dirk Kuypers
Nephrology and Renal Transplantation Research Group, Drug Delivery and Disposition, Cardiology, Abdominal Transplantation, Department of Human Genetics, Woman and Child, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE)
The use of PK/PM model-predictive control (MPC) for guiding drug dosing at thepoint-of-care (in electronic medical file/prescription), based on population pharmacokinetic (PopPK) and pharmacometric PK models (PM), that take into accountgenetic, demographic, biological and other (bio)marker parameters that influence ADME(Absorption, Distribution, Metabolism, Elimination) of narrow therapeutic drugs, can support clinicians in determiningthe ...

IL-13 secreting macrophages migrate to the lesion after intraspinal transplantation in contusion spinal cord injury and create a neuroregenerative immune environment that improves functional recovery. Hasselt University

Sven HENDRIX
Immunology & Infection, University College Dublin
The Research Council has approved the application for BOF outgoing mobility at University College Dublin, Ireland. During this stay, dr. Stefanie Lemmens will perform research in cooperation with prof. Dooley Dearbhaile.