Projects
Strategic Research Programme: Center for model-based system improvement - From Computer-Aided Engineering to Model-Aided Engineering Vrije Universiteit Brussel
iPSC Technology and Bone Regeneration KU Leuven
Bone is a calcified tissue with multiple functions. It allows movement by providing attachment points for skeletal muscle, supports haematopoiesis, stores minerals and protects soft tissues and organs. Additionally, bone has the unique capacity to regenerate upon damage without scar formation or loss of function.
Bone fracture repair recapitulates embryonic endochondral bone formation. This process is characterized by the formation of a ...
Bioprocess development for scalable production of Cartilage Intermediate Spheroids - following Quality by Design principles KU Leuven
This PhD project relies on a recent bio-mimetic methodology for in vitro process design inspired by in vivo developmental stages of tissue formation. Aim of the work is to develop and optimize the bioprocess for suspension bioreactor culture of progenitor cells to produce size-controlled µ-aggregate populations with defined chondrogenic properties. Automation aspects will be also considered in order to improve control of final product ...
Stem Cell and Stromal Vascular Fraction Treatment for Penile Tunica Albuginea and Urethral Fibrosis KU Leuven
Fibrosis is a wound healing disorder and it is defined by the excessive accumulation of fibrous connective tissue, such as collagen and fibronectin, in and around inflamed or damaged tissue. Although collagen and fibronectin deposition is an indispensable and, typically, reversible part of wound healing, normal tissue repair can evolve into a progressively irreversible fibrotic response if the tissue injury is severe or repetitive or if the ...
Near-infrared spectroscopy in the neonatal intensive care unit: can it change treatment decisions? KU Leuven
I. Introduction and background
In this proposal for PhD project we present clinical studies in different patient groups to assess cerebral oxygenation as measured with near-infrared spectroscopy (NIRS). Near-infrared spectroscopy has evolved from a purely research instrument to a monitor that is increasingly introduced into the clinical environment and especially in the neonatal intensive care unit. It has mainly been used for the ...
2D and 3D high-spatial and high-temporal resolution ultrasound imaging for characterization of tendon mechanics. KU Leuven
Achilles tendinopathy affects competitive and recreational athletes as well as inactive people. The incidence of this pathology in the general population is 1.8%and over 80% of tendon ruptures occur during recreational sports. The etiology of tendinopathies is multifactorial, but tendon overuse is assumed to be one of the main pathological stimuli.
Recently published studies have demonstrated the need for a better characterization of ...
Strategic Research Programme: Molecular Imaging and targeting of macrophages in Inflammation (ITARMI) Vrije Universiteit Brussel
BAPTON - Biology Adaptive for Proton Therapy in Oesophageal caNcer KU Leuven
More than half of the patients treated for cancer receive external Beam Radiation Therapy (EBRT) during the course of their disease. EBRT is typically characterized by highly standardized protocols and relies on the precise daily delivery of high energy X-rays combined with volumetric imaging tools. In order to further improve cancer care in Belgium, the UZ Leuven and the Cliniques Universitaires Saint-Luc have recently built in partnership ...
Settling with Waters. A Landscape Urbanism Investigation in the Sabana de Bogotá KU Leuven
In Bogotá, as in other Latin-American cities, housing demand is increasing daily, while the overall housing shortage remains an unresolved problem. Hence, flood prone areas along the Bogotá river are more and more under urbanization pressure, amongst others by low-cost housing projects, while these areas simultaneously are required in view of flooding, which promise to increase with the predictions of climate change. The dissertation ...