Role and regulation of cytoskeletal dynamics in osteoblast lineage cells: implications for fracture healing and bone tissue engineering KU Leuven
Non-healing fractures pose an increasing clinical and economical burden. Osteo-anabolic drugs to prevent osteoporosis-induced fractures and improved bone tissue engineering (BTE) strategies to treat non-unions are much sought for, and will depend on a comprehensive understanding of osteoblast biology. Osteoprogenitor migration to and proper maturation, adhesion and positioning at sites in need of bone formation are indispensible aspects of ...