Assessing the potential dual beneficial effects on bone health and global energy metabolism of hypoxia signaling pathway modulation KU Leuven
Metabolic disorders as osteoporosis, obesity and diabetes represent common comorbidities associated with poor bone quality and impaired fracture repair affecting increasing numbers of people. Interestingly, the host lab recently found that genetic activation of hypoxia signaling in osteolineage cells led to improved systemic glucose homeostasis, along with increased bone mass and vascularisation. This raises the intriguing hypothesis that ...