Identification and functional analysis of extracellular Tau species involved in the spreading of Tau pathology KU Leuven
It is the objective of this project to first fully understand what are the characteristics of this fragments present outside cells. The second main objective would be to analyze what is the functional effect of these species. This will be investigated both in vitro and in vivo, by using rat and mouse primary cultures, and the C. Elegans model, which was used already to study Tauopathies and Tautoxicity