DEMYSTIFYING ALTERNATIVE IMMUNOTHERAPY MYSTERY TARGETS BY COMBINING ARTIFICIAL INTELLIGENCE- BASED TARGET DISCOVERY AND LARGER-SCALE TARGET VALIDATION KU Leuven
While society invests big budgets in drug development, many results still end up in the Valley of Death. This could be explained by insufficient target discovery/validation and suboptimal target selection. However, even though the human genome has been mapped in 2001, a third of its coding genome remains mysterious (i.e. without annotation). Thus, this is a goldmine for target discovery, knowledge gain and drug development. This doctoral ...