Projects
Synthesis of diamino acid derivatives with a cyclopropane or aziridine skeleton and their application in the synthesis of potential physiologically active alpha,gamma-diaminobutyric acid derivates Ghent University
The synthesis of constrained A, B- or A, Y-diamino acid derivatives as building blocks for new substituted 2,4-diaminobutyric acid derivatives is of great importance in medicinal and agricultural chemisrty. This research concerns the development of stereoselective syntheses and biochemical evaluation of new derivatives of 1,2-diaminocyclopropane-1-carboxylic acid and also the stufdy of their ring opening reactions towards potentially ...
Synthesis of diamino acid derivatives with a cyclopropane or aziridine skeleton and their application in the synthesis of potential physiologically active alpha, gamma-dimainobutyric acid derivatives Ghent University
The synthesis of constrained x, B- or x, Y-diamino acid derivatives as building blocks for new substituted 2,4-diaminobutyric acid derivatives is of great importance in medicinal and agricultural chemistry. This research concerns the development of stereoselective syntheses and biochemical evaluation of new derivatives of 1,2-diaminocyclopropane-1-carboxylic acid, 2-amino-2-aziridin-2-ylacetic acid and 2-amino-3-aziridin-2-ylpropionic acid ...
Synthesis of naphthyltriazoles and applications in enantioselective synthesis. KU Leuven
Over the past few decades, atropisomers mainly based on the binaphthalene core have shown their enormous potential in various areas of chemical research. Many examples have been exploited in enantioselective reactions as the chiral transfer reagents, or as molecular pliers. Furthermore, the impact of atropisomers even reaches the medicinal chemistry field. The interests in the group of prof. Wim Dehaen have recently taken a turn towards the ...
Synthesis of diamino acid derivatives with a cyclopropane or aziridine skeleton and their application in the synthesis of potential physiologically active alpha,gamma-diaminobutyric acid derivatives. University of Antwerp
Development of new antibiotics: Synthesis of innovative aminoacylated sulfonamide nucleosides and mupirocin analogues as aminoacyl-tRNA-synthetase inhibitors KU Leuven
The alarming spread of bacterial resistance to existing antibiotics is a serious global health threat. As a result, there is an urgent need for new antibiotics which preferably act on new cellular targets that are essential for the survival of pathogens. The toxicity, selectivity, bioavailability in patients, the serum stability and, in particular, the bacterial uptake are important challenges in the development of new antibiotics.
The ...
Multilevel Synthesis of Single-Case Experimental Data: Further Developments and Empirical Validation. KU Leuven
Evaluation of furan as a strategic skeletal substructure in the synthesis of collections of molecules inspired by natural polycyclic terpenes Ghent University
Today's medical practice has been mode possible by the major technological breakthroughs of the last hundred years. Thus, patients worldwide have come to appreciate the value of centuries of fundamental scientific research and growing insights. However, few fundamental scienfici disciplines have had the direct and revolutionizing impact as that of natural product (NP) chemistry. This classical research area is devoted to isolating, ...
QSAR directed design, synthesis and evaluation of anti-invasive chalcones and related heterocyclic compounds Ghent University
Invasion and metastasis are the foremost causes of the fatal outcome of cancer and accordingly pose a main challenge in oncology. Using a predictive QSAR-model as a rationale and an in vitro assay as verification, the objective of this project is to synthesise new potent anti-invasive agents amongst the classes of chalcones and related heterocyclic compounds.
Development of a general protocol for the synthesis of conjugated block copolymers. KU Leuven
pi-Conjugated polymers are a promising class of materials because of their exceptional optic and electronic properties. They are used in high tech applications, e.g. organic solar cells, organic LEDs, supercapacitors, biosensors. Their molecular architecture and structure play a dominant role in their performance and therefore obtaining control over their synthesis is one of the main goals polymer chemists pursue nowadays. Building ...