Projects
Synthesis of diamino acid derivatives with a cyclopropane or aziridine skeleton and their application in the synthesis of potential physiologically active alpha,gamma-diaminobutyric acid derivates Ghent University
The synthesis of constrained A, B- or A, Y-diamino acid derivatives as building blocks for new substituted 2,4-diaminobutyric acid derivatives is of great importance in medicinal and agricultural chemisrty. This research concerns the development of stereoselective syntheses and biochemical evaluation of new derivatives of 1,2-diaminocyclopropane-1-carboxylic acid and also the stufdy of their ring opening reactions towards potentially ...
Synthesis of diamino acid derivatives with a cyclopropane or aziridine skeleton and their application in the synthesis of potential physiologically active alpha, gamma-dimainobutyric acid derivatives Ghent University
The synthesis of constrained x, B- or x, Y-diamino acid derivatives as building blocks for new substituted 2,4-diaminobutyric acid derivatives is of great importance in medicinal and agricultural chemistry. This research concerns the development of stereoselective syntheses and biochemical evaluation of new derivatives of 1,2-diaminocyclopropane-1-carboxylic acid, 2-amino-2-aziridin-2-ylacetic acid and 2-amino-3-aziridin-2-ylpropionic acid ...
Activity of endothelial nitric oxide synthase in a mouse model for atherosclerosis. University of Antwerp
Activity of endothelial nitric oxide synthase in a mouse model for atherosclerosis. University of Antwerp
Tumor-associated fatty acid synthase expression: impact on lipid composition and on functionality of membranes, role in cancer cell biology and applications for cancer intervention. KU Leuven
Drug development based on Thymidylate Synthase (TS). KU Leuven
Syntheses of Stimuli-sensitive Diselenide-based Macromolecules. KU Leuven
Synthesis of naphthyltriazoles and applications in enantioselective synthesis. KU Leuven
Over the past few decades, atropisomers mainly based on the binaphthalene core have shown their enormous potential in various areas of chemical research. Many examples have been exploited in enantioselective reactions as the chiral transfer reagents, or as molecular pliers. Furthermore, the impact of atropisomers even reaches the medicinal chemistry field. The interests in the group of prof. Wim Dehaen have recently taken a turn towards the ...