Projects
Risk stratification of sudden cardiac death. KU Leuven
Sudden cardiac death (SCD) is defined as a non-traumatic, fatal event occurring within 1 hour of the onset of symptoms in an apparently healthy subject. The annual incidence varies widely across different studies. In the USA reported incidences varied from 180 000 to over 450 000 cases of SCD nationwide. SCD can present as a ventricular tachyarrhytimia, either ventricular tachycardie (VT), ventricular fibrillation, pulseless electrical ...
Inflammation-based stratification for adjunctive immune targeting in major depressive disorder KU Leuven
This doctoral project will focus on the role of the immune system in the evolution and treatment of major depression. In 2018, 6% of people over the age of 15 had a depressive disorder in the Flemish Region. In 2019, this was 36 million people per year for Europe, good for 92 billion euros in annual costs. The WHO estimates that depression will be one of the leading causes of disease burden by 2030. Depression, however, is very heterogeneous, ...
Genetic risk stratification in familial idiopathic pulmonary fibrosis to refine the multimodal screening program for relatives KU Leuven
Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease. The increased burden of IPF within families, familial pulmonary fibrosis (FPF) indicates that genetic factors are important in the risk of developing IPF. To date, a number of common and rare genetic variants contributing to the risk of pulmonary fibrosis have been identified. However, the majority of these genetic risk factors still remain unknown. ...
Spinal cord injury induced autoantibodies as biomarkers for patient stratification Hasselt University
Inflammation-based stratification for immune-targeted Augmentation in major depressive disorder (INSTA-MD). University of Antwerp
TBM (Applied Biomedical Research with a Primary Societal finality) project: INSTA-MD: INflammation-based Stratification for immune- Targeted Augmentation in Major Depressive disorder Vrije Universiteit Brussel
INSTA-MD: INflammation-based Stratification for immune-Targeted Augmentation in Major Depressive disorder KU Leuven
The goal of this project is to offer a clear cut augmentation strategy for the first line treatment of major depressive disorder.
More specifically to tackle the treatment resistance (i.e. non-remission after two consecutive trials of first-line antidepressants) in 30-40% of cases, partially related to an immunemediated subtype of MDD. With the use of immune-based stratification, this immune-subtype can already be screened for by general ...
Improvement of risk stratification and treatment in acute myocarditis. University of Antwerp
Polygenic risk scores for Alzheimer’s disease prediction and stratification KU Leuven
Alzheimer’s Disease (AD) is a neurodegenerative disease characterized by the accumulation of abnormal protein aggregates in the brain, i.e. amyloid (Aβ) plaques and tau tangles. AD is the most frequent cause of dementia, with over 40 million people affected worldwide. In its final phase, progressive loss of neurons impairs memory, cognition, and other functions depending on the affected brain areas. There is currently no treatment that stops ...