The mutational landscape of in vivo and in vitro human embryogenesis KU Leuven
Early human preimplantation development is burdened with chromosome abnormalities. The remarkable genomic instability is predominantly cause by post-zygotic events, which contribute to chromosomal mosaicism. The presence of aneuploidy can be fatal to embryo, causing developmental arrest, implantation failure or adverse pregnancy outcomes. Due to its clinical relevance, the mechanisms and consequences of embryo aneuploidy are being intensively ...