Publications
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Functional interaction between PDGF beta and GluN2B-containing NMDA receptors in smooth muscle cell proliferation and migration in pulmonary arterial hypertension KU Leuven
In this study, we explored the complex interactions between platelet-derived growth factor (PDGF) and N-methyl-d-aspartate receptor (NMDAR) and their effect on the excessive proliferation and migration of smooth muscle cells leading to obstructed arteries in pulmonary arterial hypertension (PAH). We report lower expression of glutamate receptor NMDA-type subunit 2B (GluN2B), a subunit composing NMDARs expected to affect cell ...
Functional importance of the sGC isoforms (alpha(1)beta(1) and alpha(2)beta(1)) in vascular smooth muscle relaxation Ghent University
Functional importance of the soluble guanylyl cyclase isoforms (sGCU+03B11U+03B21 and sGCU+03B12U+03B21) in vascular smooth muscle relaxation Ghent University
Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle KU Leuven
In pulmonary arterial smooth muscle, Ca(2+) release from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyRs) may induce constriction and dilation in a manner that is not mutually exclusive. We show here that the targeting of different sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPases (SERCA) and RyR subtypes to discrete SR regions explains this paradox. Western blots identified protein bands for SERCA2a and SERCA2b, whereas ...
Smooth and robust estimation of mean and dispersion functions in regression models. KU Leuven
In this dissertation we discuss methods to flexibly estimate both the mean and the dispersion function in regression models. This is done combining the P-splines methods for flexible modelling of the mean function (Eilers and Marx (1996)) with different approaches employed to estimate the dispersion function in parametric modelling, namely the Double Exponential Family approach of Efron (1986) and the closely related Extended Quasi-Likelihood ...
Computing zeta functions on log smooth models KU Leuven
We establish a formula for the volume Poincaré series of a log smooth scheme. This yields in particular a new expression and a smaller set of candidate poles for the motivic zeta function of a hypersurface singularity and of a degeneration of Calabi–Yau varieties.
Integrated data depth for smooth functions and its application in supervised classification KU Leuven
© 2015, Springer-Verlag Berlin Heidelberg. This paper concerns depth functions suitable for smooth functional data. We suggest a modification of the integrated data depth that takes into account the shape properties of the functions. This is achieved by including a derivative(s) into the definition of the suggested depth measures. We then further investigate the use of integrated data depths in supervised classification problems. The ...
Sequence space representations for spaces of smooth functions and distributions via Wilson bases Vrije Universiteit Brussel
We provide explicit sequence space representations for the test function and distribution spaces occurring in the Valdivia-Vogt structure tables by making use of Wilson bases generated by compactly supported smooth windows. Furthermore, we show that these kind of bases are common unconditional Schauder bases for all separable spaces occurring in these tables. Our work implies that the Valdivia-Vogt structure tables for test functions and ...