Signal peptide-dependent ER translocation as target for selective small molecule inhibitors KU Leuven
ER protein co-translational translocation is a complex, multistep process that is essential for the metabolism and survival of cells. In fact, protein co-translational translocation is involved in many pathological conditions, such as cancer, where the growth of cancer cells is supported by upregulated protein translocation. Moreover, many viruses hijack the host cell translocation machinery for the synthesis of viral proteins and host-cell ...