Dissecting the cellular and molecular interaction networks that promote melanoma stemness at the perivascular niche. KU Leuven
Being the deadliest form of skin cancer, cutaneous melanoma represents a major clinical and societal challenge. Melanomas are made up of millions of both malignant and stromal cells, including immune cells, fibroblasts and blood vessels. Recently, the host laboratory has identified a malignant stem-like cell population that fuels tumor growth. These melanoma stem cells (MSCs) are predominantly located around blood vessels. Based on ...