Genome-wide screens using human embryonic stem cells to study cell state transitions and diseases of skeletal muscle. KU Leuven
Identification of essential genes regulating the maintenance of and changes in cell identities is vital to gain a better control over these processes, and to ultimately achieve fundamental aims in regenerative medicine, including cell therapies and in vivo reprogramming for tissue repair. In my postdoctoral work, I established a genome-wide CRISPR/Cas9-based screening platform in haploid human embryonic stem cells (hESCs) and used it as a ...