Projects

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GPR18 as novel target to treat visceral pain KU Leuven

Guy Boeckxstaens
Translational Research in GastroIntestinal Disorders
Visceral pain is a hallmark symptom of the irritable bowel syndrome (IBS) for which no efficient treatment is available. It results from sensitisation of TRP (transient receptor potential) channels located on visceral afferent nerves, a phenomenon mediated by histamine released by mast cells. Histamine 1 receptor antagonism blocks TRP sensitisation and improves symptoms in 50% of IBS patients. As TRP channels are also sensitised by other mast ...

Sensitisation profiles to nonspecific-lipid transfer proteins (ns-LTP): gaining insights into the kaleidoscope of IgE reactivity profiles and clinical phenotypes. University of Antwerp

Margo Hagendorens
Immunology, Laboratory Experimental Medicine and Pediatrics (LEMP)
Nonspecific-lipid transfer proteins (ns-LTPs) have increasingly been recognized to constitute a significant cause of plant food allergy. Sensitization to ns-LTPs was predominantly observed in adults and appeared mainly associated with severe generalized reactions. However, we established that in northern Europe sensitization to ns-LTP can also occur in children and that the sensitization profile assessed by quantification of specific IgE ...

Analysing and Modulating Apoptosis Sensitisation and Resistance in Cultured and Patient-Derived Cardiac Cells by Quantitative Biochemistry and Computational Systems Biology Implications to Cardiotoxicity and Differentiation. KU Leuven

Heinrich Huber
Department of Cardiovascular Sciences, University of Central Lancashire
Deregulated apoptosis resulting in a loss of cardiomyocytes has been implicated in malignant cardiac remodelling after exposure with the chemotherapeutic doxorubicin (DOX), resulting in cardiac impairment later in life. While differentiated primary cells such as cardiomyocytes are usually very robust to apoptosis, evidence has been provided that their toxic exposure may make them susceptible to further injury. We therefore ask here if ...

Mechanisms underlying airway sensitisation and tolerance towards major allergens of Dermatophagoides mites. KU Leuven

Jan Ceuppens
Allergy and Clinical Immunology Research Group, Inborn Errors of Immunity, Centre for Molecular and Vascular Biology
Several data suggest that a deficiency in regulatory T (Treg) cells underlies the loss of tolerance and uncontrolled sensitization to harmless environmental (food and inhaled) allergens in atopic subjects. Concentrating on clinically relevant recombinant allergens from a major allergen source, house dust mites (HDM), we intend to further document and define this deficiency as well as its consequences, and to find new original approaches to ...

Consortium Preventive Oral Health Care as partner organisation for preventive oral health care in a risk population. KU Leuven

Joke Duyck
Population Studies in Oral Health

This project aims to contribute to facilitate oral health and prevention of oral disease of the population, and more specifically in risk populations by means of development of methodologies, sensitisation, structural measures, as well as help and guidance during implementation of the latter by intermediate organisations. The populations will be reached by relevant intermediate organisations in order to achieve the policy priorities and ...

Reintegration of inmates and ex-offenders through employment in an inclusive and sustainable manner. KU Leuven

Hilde Breesch
Construction Technology, Ghent and Aalst Technology Campuses

In the short term the challenges of the project are to (1) Create a frame for orienting inmates and ex-offenders to suitable housing and employment. This frame consists in sensitising and unburdening potential employers in the construction and agricultural sector when recruiting, training and employing inmates and ex-offenders; identifying houses, followed by the setting up of innovative learning environments; energy-efficient renovation of ...

Potential interactions between peripheral and central mechanisms in patients with chronic whiplash : does reduction in white matter integrity play a role in this traumatic event? Ghent University

Mira Meeus
Department of Rehabilitation Sciences and Physiotherapie

The aim of this project is to explore the interrelationship between changes in muscle function, central pain mechanisms and white matter integrity in patients with chronic whiplash associated disorders (WAD). 35 subjects in each group (traumatic neck pain, non-traumatic neck pain and healthy controls) will undergo a series of investigations, including evaluation of muscle performance, muscle properties, white matter integrity and central pain ...