Financing IOF-program: Camelidae-derived single-domain antibody fragments for theranosis of cancer Vrije Universiteit Brussel
Single domain antibodies that neutralize SARS-CoV-2 Ghent University
The aim of this project is to isolate single domain antibodies that are directed against the receptor-binding domain that is part of the spike protein of SARS-CoV-2. Those single-domain antibodies, separately and combined, will be evaluated for their capacity to neutralize SARS-CoV-2.
Perturbation of apolipoprotein E4 (apoE4) activity in AD pathology using single domain antibodies and targeting them to the brain Ghent University
The APOE-ε4 allele is the most prominent genetic risk factor for late onset AD. We will use ApoE4 nanobodies to stabilize the non-pathological conformation of ApoE4, and use photoporation as a means of introducing nanobodies in mammalian cells. In addition, we plan to target nanobodies to the brain in collaboration with prof. Breakefield (Dept. Neurology, Harvard Medical School, Boston).
Nanobodies in Health : Next generation Antibody fragments for Medical Applications Vrije Universiteit Brussel
New antivirals against human parainfluenza virus Ghent University
Human parainfluenza viruses (hPIVs) are a major cause of severe respiratory disease in (very) young children and the immunocompromised. hPIVs are the second main cause of hospitalization due to acute respiratory tract infection in children under five (respiratory syncytial virus ranks first). There are no clinically approved vaccines or antivirals available against hPIVs to prevent or treat these infections. Our group recently isolated ...
IOF Accelerator: “FLT imaging using Nanobodies: effective tool for life sciences and medical applications (NLITE) Vrije Universiteit Brussel
IOF Accelerator: Camelidae-derived single domain antibody fragments for theranosis of cancer Vrije Universiteit Brussel
New and innovative antimicrobial solutions against microbial biofilms and fungal infections, with applications in the medical and agrochemical domain KU Leuven
The primary aim of this IOF mandate is the identification of novel antifungal and/or antibiofilm molecules. Focus is on novel molecules or combinations of molecules that are effective against resistant fungi and/or fungal biofilms; and on the unraveling of their mode of action. This research forms the basis for valorisation in the following domains (i) treatment/control of fungal infections in human, animal, and plant context; as well as (ii) ...
Aggregation as a mechanism for p53 oncogenic transformation: clinical relevance and new tools for its study KU Leuven
The p53 tumor suppressor is one of the most frequently mutated genes in human cancers, up to 50% of all cancers. This event has three different consequences: (i) Loss-of- function, (ii) Dominant-negative activity, i.e. reduced amount of active p53 due to the incorporation of wild-type and mutant monomers into the mixed tetramer, and (iii) Gain-of-function, that is, the ability of mutant p53 to interact with other proteins and inactivate them. ...