Comprehensive genomic and transcriptomic analysis of high grade serous ovarian cancer using single-cell RNA-sequencing. KU Leuven
In this project, we employ an innovative technique called single-cell RNA-sequencing (scRNA-seq) on thousands of randomly dissociated celis from consecutive tumour biopsies of high grade serous ovarian cancer (HGSOC) patients before and during first-line treatment but also at moment of relapse. ScRNA-seq enables us to detect transcriptomic heterogeneity, both in cancer cells and their surrounding stromal celis (Le. microenvironment) down to ...