Tumor vessel co-option at single-cell resolution KU Leuven
Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy. The heterogeneity of co-opted endothelial cells and pericytes, co-opting cancer and myeloid cells in tumors growing via vessel co-option, has not been investigated at the single-cell level. Here, we use a murine anti-angiogenic therapy-resistant lung tumor model, in which vascular endothelial growth factor-targeting induces vessel ...