Projects
nD: Multi-dimensional dynamical models, (multi-)linear numerical algorithms and tensor data. KU Leuven
Model-based prediction of post-treatment walking patterns in cerebral palsy to support clinical decision making KU Leuven
Drug solubility in human intestinal fluids: multi-objective analysis and modelling KU Leuven
Molecular Investigation of Pathways in Evolutionary Toxicology KU Leuven
Inferring the cross-species connectivity of signal transduction pathways serves two key purposes. First, it helps determine the potential impact on a species when a pathway is triggered. Second, it establishes whether the pathway is conserved across evolution. This knowledge aids in selecting appropriate test systems for predicting chemical-induced toxicity in humans and establishing human disease models in other species.
This study ...
Rational Design of XNA Processing Enzymes KU Leuven
Xenobiotic Nucleic Acids (XNA) are synthetic analogues of natural nucleic acids (DNA and RNA). They are developed for applications such as therapeutics, diagnostics and alternative carriers of genetic information. The main goal of the PhD research is to develop a 'toolbox' with enzymes for XNA in molecular biology that is based on rational insights.
In chapter 2, currently available computer-driven algorithms were explored for their ...
Cardiac mechanobiology-on-a-chip (COACH). KU Leuven
BIOARCHiTECT - Precision BIOmanufacturing of hierARCHIcal joint implants for osTEoCHondral regeneration KU Leuven
Mathematical and Experimental Immunology. University of Antwerp
Data-driven generation of individualized human heart models form scalable heart muscle sheets KU Leuven
Proper cardiac function requires the heart cells to mediate a non-linear wave of electrical depolarization and repolarization. Abnormalities in these electrical patterns underlie lethal cardiac arrhythmias. Additionally, chronic atrial arrhythmias cause 1/4 of stroke cases. Multiple treatment options for arrhythmias with drugs, devices or ablation are still based on the electrocardiogram, which only offers a projection of the heart's ...