EphB2-ephrin-B2 and NMDA receptor signaling as underlying mechanism of visceral hypersensitivity KU Leuven
Abdominal pain is one of the most difficult to treat symptoms in patients suffering from Functional Gastro-Intestinal Disorders (FGIDs). Recent evidence shows that visceral hypersensitivity (VHS), represents an important underlying mechanism. The most common and most studied FGID is Irritable Bowel Syndrome (IBS), characterized by chronic discomfort and abdominal pain associated with altered defecation in the absence of an organic cause. ...