A multidisciplinary approach using global metabolomics, genomescale metabolic modelling, shRNA screen and biological validation to discover novel pro-angiogenic metabolic targets. KU Leuven
Angiogenesis (growth of new blood vessels) is of vital importance for development and health, but also contributes to multiple pathological conditions. Anti-angiogenic drugs are routinely used for treatment of blinding ocular disease and various types of cancer. However, the success of these therapies for cancer is limited by the lack of efficacy and resistance. There is thus an urgent need for alternative anti-angiogenic strategies, based on ...