Publications
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Aqueous self-assembly of a wide range of sophorolipid and glucolipid microbial bioamphiphiles (biosurfactants) : considerations on the structure-properties relationship Ghent University
Sophorolipids are well-known scaled-up microbial glycolipid biosurfactants with a strong potential for commercialization due to their biological origin and mildness in contact with the skin and the environment compared to classical surfactants. However, their association properties in water are still poorly understood, they cannot be predicted and their behavior in solution challenges half a century of knowledge generated in the field of ...
Characterisation of the structure and self-assembly of a small cyclic peptide: an analysis using NMR spectroscopy, diffusion and heteronuclear relaxation measurements Ghent University
Pseudodesmin A, a member of the viscosin group, is a cyclic lipodepsipeptide (CLP) consisting out of an oligopeptide that is cyclised through a lactone bond between its C-terminal carboxyl group and the hydroxyl group of a threonine side chain and a 3-hydroxydecanoic acid moiety bonded to the N-terminal end of the peptide. It is found to self-assemble in apolar organic solvents, which is reminiscent of its expected ability of forming ion pores ...
Influence of Centrifugation and Shaking on the Self-Assembly of Lysozyme Fibrils Vrije Universiteit Brussel
Protein self-assembly into fibrils and oligomers plays a key role in the etiology of degenerative diseases. Several pathways for this self-assembly process have been described and shown to result in different types and ratios of final assemblies, therewith defining the effective physiological response. Known factors that influence assembly pathways are chemical conditions and the presence or lack of agitation. However, in natural and ...
Influence of chain length of gradient and block copoly(2-oxazoline)s on self-assembly and drug encapsulation Ghent University
Amphiphilic gradient copolymers represent a promising alternative to extensively used block copolymers due to their facile one-step synthesis by statistical copolymerization of monomers of different reactivity. Herein, an in-depth analysis is provided of micelles based on amphiphilic gradient poly(2-oxazoline)s with different chain lengths to evaluate their potential for micellar drug delivery systems and compare them to the analogous diblock ...
Kinetic Control of Aggregation Shape in Micellar Self-Assembly Hasselt University
The first steps towards top-down morphology control in micellar self-assembly are introduced. Kinetically stable micelles are formed from block copolymers (BCPs) using continuous flow techniques by turbulent mixing of water with a THF solution of polymers. In this way, particle shape and size can be altered from spheres to ellipsoids solely via tuning of mixing parameters from a single BCP.
Hydrophobic melanin via post-synthetic modification for controlled self-assembly Ghent University
Allomelanin is a class of nitrogen-free melanin mostly found in fungi and, like all naturally occurring melanins, is hydrophilic. Herein, we develop a facile method to modify synthetic hydrophilic allomelanin to yield hydrophobic derivatives through post-synthetic modifications. Amine-func-tionalized molecules of various kinds can be conjugated to allomelanin nanoparticles under mild conditions with high loading efficiencies. Hydrophobicity is ...
Self-assembly of Tween 80 micelles as nanocargos for oregano and trans-cinnamaldehyde plant-derived compounds Ghent University
The self-assembly of Tween 80 (T80) micelles loaded with plant-based oregano essential oil (OR) and trans-cinnamaldehyde (TCA) was studied. The effect of different factors, including the surfactant to oil ratio, the presence of sodium chloride, thermal treatment, and dilution on their formation and physicochemical stability was evaluated. The creation of nano-cargos was confirmed by TEM. The self-associated structures had z-average droplet ...
Self-assembly of microsystem components with micrometer gluing pads through capillary forces Hasselt University
The self-alignment of microparts based on capillary forces and micrometer adhesive pads was evaluated through experimental evidence, analytical modelling and simulation. The local deposition of adhesive pads in the range of 2000 to 20 mu m was realized by photo-lithographical patterning of an acrylate adhesive interlayer, followed by the spontaneous assembly with glass counterfaces that have a complementary array of hydrophobically modified gold ...