Projects
The rational design and validation of a Salmonella Typhimurium vaccin by deletion of virulence genes for use in pigs Ghent University
In this project, extensively characterized, live, attenuated vaccinstrains of Salmonella Typhimurium are made. These strains should evoke a good protection against a Salmonella infection in pigs and be attenuated in humans, animals and the environment. In addition, the pigs vaccinated with these strains, should be serologically distinguishable from pigs infected with field strains of Salmonella in the current national Salmonella pig control ...
Proteogenomic-assisted exploration of the molecular mechanisms underlying Salmonella infection Ghent University
In recent years, high-throughput techniques such as next-generation sequencing allowed us to study complex biological processes at a comprehensive, genome-wide scale. Such techniques became a
platform for the development of novel, more specialized tools. A
paragon example of this is the ribosome profiling technique that
enabled the global measurement of protein synthesis, translation, by
sequencing of ...
The involvement of multidrug resistance pumps in the survival of Salmonella Enteritidis in egg white. Ghent University
Salmonella Enteritidis is superior in colonizing egg white. Host stress induced changes in the egg white peptide composition, may result in survival of Salmonella which is using multidrug resistance pumps to export egg white-derived antimicrobial agents. Unraveling the differential expression in stressed animals and identity of egg white components exported by Salmonella is of crucial importance in understanding egg infections.
Investigation of the influence of prophages on the physiology and virulence of emerging invasive non-typhoid Salmonella Typhimurium (iNTS) KU Leuven
Bacteria are engaged in a never-ending struggle with their viral predators, termed bacteriophages or phages. This resulted in millennia of intimate co-evolution between bacteria and their viruses, thereby fueling the development of sophisticated infection dynamics. One of these peculiar interactions, is the formation of a phage carrier state by temperate phage P22 upon infection of its host, Salmonella Typhimurium. This phenomenon ...
Request for assistance in statistical evaluation of the achievement by Member States of the EU Salmonella reduction targets in animal populations. Hasselt University
Role of stress in Salmonella reexcretion by pigs Ghent University
Stress associated reexcretion of Salmonella Typhimurium by pigs shortly before slaughter results in carcass contamination and thus Salmonella contamination of pork (productes). In this project, the mechanism of stress associated reextreation of Salmonella by pigs will be examined using in vitro and in vivo models.
The presence, sources and transmission routes of important foodborne pathogens: Salmonella in poultry and pigs, Taenia and Sarcocystis in cattle. Ghent University
Salmonella, Sarcocystis and Taenia are important foodborne pathogens commonly found in poultry, pork, and beef. Increased knowledge on their occurrence and transmission are essential for control. Therefore, sources and transmission routes of Salmonella spp. during the slaughter process of poultry and pigs, and occurrence of Sarcocystis spp. as well as environmental contamination with Sarcocystis- and Taenia spp will be studied.
Importance of Salmonella biofilm exopolymeric substances (EPS) during gut colonization and invasion — potential of EPS inhibition as an evolutionary robust antimicrobial strategy KU Leuven
Foodborne illnesses remain a significant global public health problem with large economic consequences, despite the strict regulations regarding food safety. Salmonella represents the most common cause of bacterial foodborne outbreaks. We hypothesize that the publicly available exopolymeric substances (EPS) of the biofilm matrix made by this pathogen play an important role in gut colonization and invasion. EPS are therefore considered as ...
Molecular elucidation of the evolutionary success of salmonella Kentucky ST198 KU Leuven
Salmonella enterica serovar Kentucky (S. Kentucky) is a common cause of gastro-enteritis. Although resistance to critically important antibiotics for human medicine is rare among Salmonella species, the clonal variant S. Kentucky ST198 poses an exemption. Phylogeographic analysis indicates this clone first emerged in Egypt around 1989, before disseminating into Northern, Southern and Western Africa, and then further to the Middle East, Asia ...