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Salmonella Paratyphi A: The emergence of a neglected pathogen in Asia

Introduction

Salmonella
The Gram-negative bacteria Salmonella causes a variety of clinical syndromes in humans, ranging from a mild gastro-enteritis to a life-threatening blood stream infection. Most widely known are the serovars Salmonella Typhi and Salmonella Paratyphi A that cause typhoid and paratyphoid fever respectively (also known combined as ‘enteric fever’). In contrast with other, non –typhoidal, Salmonella serovars ...

Guarantee the safety of live Salmonella vaccines by introducing deletions in genes crucial for egg contamination Ghent University

Filip Van Immerseel
Department of Pathobiology, Pharmacology and Zoological Medicine

Salmonella enterica subspecies enterica serovar Enteritidis is a pandemic pathogen, present in
countries with industrial poultry production since the 1990s. Ingestion of this foodborne
pathogen by humans results in gastroenteritis and is linked to contaminated eggs and egg
products. Salmonellosis caused by Salmonella Enteritidis in chickens however does not lead to
clinical symptoms but causes enormous economic losses. ...

Effect of vaccination against Salmonella Typhimurium in pigs under field conditions Research Institute for Agriculture, Fisheries and Food

Geertrui Rasschaert, Marc Heyndrickx
Food Safety, Technology and Food Science
Main research question/goal
The general aim of the project is to improve the control of Salmonella infections of pigs to deliver scientifically sound advice about the effect of vaccination against Salmonella under field conditions and its eventual implementation in a national control program. The specific objectives are: 1. To investigate to which extent vaccination of sows and/or piglets can play a role in the control of Salmonella ...

Predicting and treating non-typhoidal Salmonella bloodstream infection in children in sub-Saharan Africa KU Leuven

Jan Jacobs
Laboratory of Clinical Bacteriology and Mycology, Woman and Child

Unlike in Northern countries, where non-typhoidal Salmonella causes self-limiting diarrhea, non-typhoidal Salmonella is the most common cause of bacterial bloodstream infections in children in sub-Saharan Africa. Case fatality is between 20-30%. Susceptible hosts include children with Plasmodium falciparum (Pf) malaria, severe anemia, acute malnutrition, and HIV infected individuals. Salmonella ...

Innovative feed additives for the reduction of Salmonella contaminated pork - II Research Institute for Agriculture, Fisheries and Food

Geertrui Rasschaert
Food Safety, Technology and Food Science
Main research question/goal
Is it possible to reduce Salmonella shedding by pigs by using innovative feed additives? If so, this could result in fewer Salmonella shedding pigs being delivered to the slaughterhouse. That in turn reduces the risk of meat being contaminated with this bacterium during the slaughter process. The ultimate goal is to reduce the number of human Salmonella cases and to maintain the strong ...

Interference with defensive responses in pathogenic communities at the host interface: A modelling approach towards an integrated strategy for Salmonella control in chickens. KU Leuven

Jan Paeshuyse
Chemical & Biochemical Process Technology & Control (BioTec+), Centre of Microbial and Plant Genetics, Division Animal and Human Health Engineering

Bacteria in the gut live in dense and genetically diverse communities, in which they strongly compete with each other for resources and space. A key corollary of the importance of competition is that it should strongly shape bacterial regulatory networks. Indeed, natural selection should favor cells that can detect and respond appropriately to the presence of competing strains. We hypothesize that these defensive responses to competition are ...

Interference with defensive responses in pathogenic communities at the host interface: A modelling approach towards an integrated strategy for Salmonella control in chickens KU Leuven

Jan Van Impe
Chemical & Biochemical Process Technology & Control (BioTec+), Centre of Microbial and Plant Genetics, Animal and Human Health Engineering (A2H)
Bacteria in the gut live in dense and genetically diverse communities, in which they strongly compete with each other for resources and space. A key corollary of the importance of competition is that it should strongly shape bacterial regulatory networks. Indeed, natural selection should favor cells that can detect and respond appropriately to the presence of competing strains. We hypothesize that these defensive responses to competition are at ...

The effect of bacterial warfare on resistance in Salmonella. Towards a more optimal selection of Live Microbial Formulations. KU Leuven

Hans Steenackers
Microbial and Plant Genetics (CMPG), Centre of Microbial and Plant Genetics

Due to the over- and misuse of antibiotics over the past decades, resistant pathogens withstanding antibiotic treatments are on the rise. A trend of increasing drug resistance has also been observed for non-typhoidal Salmonella, which is one of the primary causes of foodborne disease and has the highest disease burden among enteropathogens. Since the prevalence of antibiotic (multi-)resistant Salmonella species is ...

Asses the variation in lipopolysaccharide structure in circulating African invasive Salmonella Typhimurium isolates to predict vaccine coverage. University of Antwerp

Sandra Van Puyvelde
Laboratory of Medical Microbiology (LMM)
In sub-Saharan Africa, invasive non-typhoidal Salmonella (iNTS) is the major cause of bacterial bloodstream infections among young children and disease management is jeopardised by increasing antimicrobial resistance (AMR). The O-antigen portion of Salmonella lipopolysaccharide (LPS) is recognised as key target antigen for protective immunity and O-antigen-based vaccines covering the main serovars Salmonella Typhimurium and Enteritidis are in ...

Identification of new Salmonella biofilm inhibitors through a 'bottom-up' and 'top-down' approach. KU Leuven

Jozef Vanderleyden
Centre of Microbial and Plant Genetics
A major difficulty in the control of Salmonella</>, and by extension most bacterial species, is the fact that they are able to develop multicellular, surface associated structures, termed biofilms. In these biofilms the bacteria are engulfed in a self-produced, gel-like matrix and are protected against many different stress factors, including antibiotics, disinfectants and immune defenses. Therefore, the main objective of this thesis was ...