Counteracting sarcopenia through exercise. KU Leuven
As our understanding of the complex process of aging ...
The ability of the muscles to generate force quickly, also referred to as power, is crucial in daily activities. Consequently, reduced muscle power has been proposed as an important predictor of age-related decline in functional performance. Optimally, functional assessments should both be applicable in clinical settings and sensitive to changes. This would enable frequent assessments and thus to initiate preventive programs in time. Stair ...
According to alarming reports of the World Health Organization, worldwide more people die
from the consequences of overfeeding than from hunger. Sedentary lifestyle and excess food
consumption have indeed provoked a worldwide obesity epidemic. Importantly, obesity is not
just a cosmetic problem, but predisposes to the development of chronic metabolic diseases,
including Type 2 diabetes (T2D) and ...
Public health initiatives promoting physical activity and exercise are important to prevent and treat chronic diseases. In order to understand the underlying mechanism, we have to realize that ‘every cell counts’ in the diversity of ways the human body adapts to exercise. This is especially true for skeletal muscle, which is the main target organ for adaptations to benefit health and performance. The current project aims to expand muscle ...
This project aims to investigate the role of carnosine, a dipeptide consisting of beta-alanine and histidine and with a high muscle concentration, on the homeostasis during contractions. Additionally, we investigate the influence of carnosine availability on the development of skeletal muscle insulin resistance and diabetes.
Type-2 diabetes is a major health problem worldwide and the prevalence keeps surging. Exercise and diet interventions are first-line procedures in diabetes prevention and management. However, the predisposition to the development of insulin resistance and the action needed to stay healthy may differ markedly at the individual level. To understand this, we must address the diversity in skeletal muscle composition - the primary glucose-disposal ...