Human pluripotent stem cells as models for disease Vrije Universiteit Brussel
Human pluripotent stem cells (hPSC) such as human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) have been proposed as powerful tools for disease modelling, since they can be obtained from affected patients and embryos, and because of their ability to differentiate into any tissue of the human body. A general strategy consists in obtaining either hESC that carry a monogenic disease after preimplantation genetic diagnosis ...