Cellular and Extracellular Matrix-Mimetic Cues for Bioprinting the Next Generation of Regenerative Constructs KU Leuven
Large and complex bone fractures rarely heal. This is due to several reasons including the severely damaged surrounding environment, insufficient nutritional supply and the lack of a critical number of stem cells required to produce new bone tissue. Standard treatment of these fractures today involve autologous or allograft transplantation, limited by tissue availability, donor site morbidity and graft rejection. Subsequently, alternative ...