Projects
Cellular and Extracellular Matrix-Mimetic Cues for Bioprinting the Next Generation of Regenerative Constructs KU Leuven
Large and complex bone fractures rarely heal. This is due to several reasons including the severely damaged surrounding environment, insufficient nutritional supply and the lack of a critical number of stem cells required to produce new bone tissue. Standard treatment of these fractures today involve autologous or allograft transplantation, limited by tissue availability, donor site morbidity and graft rejection. Subsequently, alternative ...
Mining the extraordinary regeneration potential of Marchantia polymorpha to increase regeneration of crop species Ghent University
The plant lineage displays an unrivalled regeneration capacity that not only restores damaged tissue but can also give rise to whole plant bodies. Unfortunately, many economically and ecologically important species display a poor regeneration potential. E.g., many elite tree species are recalcitrant to routine propagation by stem cuttings. In agricultural species, the capacity to regenerate is even worse, as most cereals, including important ...
Can tissue regeneration be induced via redox manipulation? An indepth characterization of the redox signature during the initial steps of regeneration. Hasselt University
The biggest fish to fry in neurodegenerative pathologies: elucidating pathways regulating neuronal regeneration in the senescent killifish KU Leuven
Due to the rise in life expectancy, age-related neurodegenerative
diseases show an increasing prevalence. As adult mammals lack the
robust capacity to regenerate lost or damaged neurons, age-related
deterioration of the central nervous system (CNS) seriously
constrains life quality and overall wellbeing of our elderly population.
In contrast to mammals, the short-lived killifish has the remarkable
ability to ...
Dendritic mitochondrial energy channeling as driver of successful axonal regeneration? KU Leuven
Treating ischemic and traumatic central nervous system (CNS) insults as well as neurodegenerative disorders like Alzheimer's and Parkinson's disease, multiple sclerosis and glaucoma, is one of the leading medical and socioeconomic challenges faced by our aging society. These currently incurable conditions lead to progressive neuronal degeneration and irreversible impairments in the adult mammalian CNS, as damaged neurons cannot be repaired, ...
Neuroinflammation as driving force for axonal regeneration in the adult mouse visual system: MMP2 as a possible modulator KU Leuven
Neurodegenerative disorders such as Alzheimer's (AD), Parkinson's (PD), and Huntington's disease, multiple sclerosis (MS), glaucoma, etc., represent a growing social and economic problem. This irreversible diseases usually occur later in life and affect an increasing number of people in our the aging society. Neurotrauma or degeneration drastically diminishes the quality of life and leads to severe impairments, largely because the central ...
Development of a smart bioactive dental cement with targeted and stimulus dependent controlled drug delivery for pulp regeneration. Ghent University
Dental trauma and caries are the two most common reasons for decreased Oral Health Related
Quality of Life. Dental pulp is the innermost layer of a tooth made up of living tissue. It is
responsible for root strength, root growth and innervation in immature permanent teeth. In case
of pulp infection due to dental caries or trauma, the infected pulp is removed and pulp therapy is
carried out with dental cements. This ...
Frontotemporal lobar degeneration (FTLD), a young-onset dementia characterized by the progressive degeneration of the frontal and temporal lobes of the human brain. University of Antwerp
Identification of the critical in vivo processes that initiate and orchestrate successful bone regeneration. KU Leuven
Bone possesses an intrinsic capacity to repair in response to injury. Bone repair is however insufficient to bridge large bone defects caused by trauma, tumor resection and skeletal deformities. A widely used therapy is bone grafting, but this strategy has major drawbacks and a search for novel strategies is thus highly needed. Bone tissue engineering is a promising approach that uses stem cells in combination with biomaterials and growth ...