Publications

An increasing number of examples in the literature suggest that the in vivo duration of drug action not only depends on macroscopic pharmacokinetic properties like plasma half-life and the time needed to equilibrate between the plasma and the effect compartments, but is also influenced by long-lasting target binding and rebinding. The present review combines information from different research areas and simulations to explore the nature of these ...

Importance of the field: It is well established that the in vivo duration of drug action not only depends on macroscopic pharmacokinetic properties like its plasma half-life, but also on the residence time of the drug-target complexes. However, drug `rebinding' (i.e., the consecutive binding of dissociated drug molecules to the original target and/or targets nearby) can be influential in vivo as well.

Areas covered in this review: ...

Introduction
In many situations, optimal drug therapy requires continuing, high levels of target occupancy and this notion has led pharmacologists to focus attention to the rate by which drug candidates dissociate from their target. To this end, radioligand dissociation experiments are often carried out on in vitro models such intact cells and membranes thereof but the interpretation of the collected data is sometimes ambiguous.
Areas ...

Cytoglobin (Cygb) was recently discovered in the human genome and localized in different tissues. It was suggested to play tissue-specific protective roles, spanning from scavenging of reactive oxygen species in neurons to supplying oxygen to enzymes in fibroblasts. To shed light on the functioning of such versatile machinery, we have studied the processes supporting transport of gaseous heme ligands in Cygb. Carbon monoxide rebinding shows a ...

In the recent literature, a rewinding approach was proposed to construct a rewound five-phase machine with either star-connected or combined star-pentagon configuration using the existing three-phase stators. For the same rated power of the machine, the power per phase decreases by a factor 3/5 in the five-phase machine, compared to the three-phase machine. This means either the rated current or the rated voltage must be rescaled. The constant ...

Film type materials often have to be processed. A reel of film is unwinded, the film passes over several rollers along the processing units and is rewinded. Since the diameters of both reels vary in time, one or more dancing rollers are used to cope with imperfect matching of unwinding and rewinding speeds. This research aims at an alternative control system for the motors driving the reels. The new control system should avoid the numerous ...

The purpose of this study was to provide normative data for a Flemish version of the Buschke Selective Reminding Test (SRT). The SRT allows for the simultaneous analysis of several components of verbal memory, such as short and long term retrieval. The Flemish SRT was administered to 3257 neurologically healthy adults (1627 men and 1630 women, age range = 18–94 years). Effects of age, sex and education on SRT performance were assessed. Results ...

Traditionally it is assumed that modern civil society originated in the associations, clubs, and public sphere of the eighteenth century as a result of the liberation of the individual from the shackles of absolutism, religious intolerance, and the patriarchal family. However, recent research goes further back in time. Scholars such as Robert Putnam (sociologist), Antony Black (political scientist), and Katherine Lynch (historian) associate the ...

Due to the unique geometry, dual-panel PET scanners have many advantages in dedicated breast imaging and on-board imaging applications since the compact scanners can be combined with other imaging and treatment modalities. The major challenges of dual-panel PET imaging are the limited-angle problem and data truncation, which can cause artifacts due to incomplete data sampling. The time-of-flight (TOF) information can be a promising solution to ...