Rational design of small molecule modulators targeting the transcriptional function of the Salmonella Typhimurium response regulator PhoP KU Leuven
Pathogenic bacteria have acquired resistance against most clinical antibiotics. Infectious diseases caused by these bacteria are one of the biggest challenges in public health. There is an urgent need to develop new mechanisms to treat infectious diseases. Traditional antibiotics are designed for their ability to kill or inhibit the growth of pathogens. Both mechanisms induce strong selective antibiotic resistance pressure. It has been ...